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Article

Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression.

Scientific reports - 18 Aug 2017

Nygaard Gyrid, Herfindal Lars, Asrud Kathrine S, Bjørnstad Ronja, Kopperud Reidun K, Oveland Eystein, Berven Frode S, Myhren Lene, Hoivik Erling A, Lunde Turid Helen Felli, Bakke Marit, Døskeland Stein O, Selheim Frode

Abstract excerpt

Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1-/- mice, but not Epac2-/- mice, have prolonged bleeding time, suggesting that Epac1 may limit fluid loss also by restraining bleeding. The Epac1-/- mice had deficient in vitro secondary hemostasis. Quantitative comprehensive proteomics analysis revealed that...

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Identifiers

PMID: 28821815
DOI: 10.1038/s41598-017-08975-y
PMCID: PMC5562764

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