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Article

Plasmin generates vasoinhibin-like peptides by cleaving prolactin and placental lactogen.

Molecular and cellular endocrinology - 1 Dec 2021

Friedrich Christin, Neugebauer Leon, Zamora Magdalena, Robles Juan Pablo, Martínez de la Escalera Gonzalo, Clapp Carmen, Bertsch Thomas, Triebel Jakob

Abstract excerpt

Vasoinhibin is an antiangiogenic, profibrinolytic peptide generated by the proteolytic cleavage of the pituitary hormone prolactin by cathepsin D, matrix metalloproteinases, and bone morphogenetic protein-1. Vasoinhibin can also be generated when placental lactogen or growth hormone are enzymatically cleaved. Here, it is investigated whether plasmin cleaves human prolactin and placental lactogen to generate...

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Identifiers

PMID: 34601001
DOI: 10.1016/j.mce.2021.111471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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