Article
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 1994
Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, Breukel C, Alt E, Lipkin M, Khan P M
Abstract excerpt
Germ-line mutations in the human adenomatous polyposis coli (APC) gene result in familial adenomatous polyposis, an autosomal dominant disorder characterized by the early onset of multiple adenomatous polyps in the large bowel with a high likelihood of developing colorectal carcinomas. To understand the role of APC in intestinal tumor formation, we have introduced a chain-termination mutation in the 15th exon of...
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