Article
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice.
Gastroenterology - 1 Oct 2000
Smits R, Ruiz P, Diaz-Cano S, Luz A, Jagmohan-Changur S, Breukel C, Birchmeier C, Birchmeier W, Fodde R
Abstract excerpt
BACKGROUND & AIMS: Inactivation of the adenomatous polyposis coli (APC) gene is observed at early stages of intestinal tumor formation, whereas loss of E-cadherin is usually associated with tumor progression. Because both proteins compete for the binding to beta-catenin, an essential component of the Wnt signaling pathway, reduction of E-cadherin levels in an Apc mouse model could influence both tumor initiation...
Topics
- Adenomatous Polyposis Coli Protein
- Alleles
- Animals
- Cadherins
- Chromosome Mapping
- Cytoskeletal Proteins
- Disease Models, Animal
- Female
- Gastric Mucosa
- Genes, APC
- Heterozygote
- Intestinal Mucosa
- Intestinal Neoplasms