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Article

Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis.

Gut - 1 Apr 2008

Wapenaar M C, Monsuur A J, van Bodegraven A A, Weersma R K, Bevova M R, Linskens R K, Howdle P, Holmes G, Mulder C J, Dijkstra G, van Heel D A, Wijmenga C

Abstract excerpt

BACKGROUND: Coeliac disease (gluten-sensitive enteropathy; GSE) and inflammatory bowel disease (IBD) are common gastrointestinal disorders. Both display enhanced intestinal permeability, initiated by gluten exposure (GSE) or bacterial interactions (IBD). Previous studies showed the association of both diseases with variants in MYO9B, presumably involved in epithelial permeability. AIM: It was hypothesised that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17989107
DOI: 10.1136/gut.2007.133132

Genes

PARD3
MAGI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis.PMID 17989107Read ↗

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Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.Semantic proximity Read ↗

A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease.Semantic proximity Read ↗

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Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability.Semantic proximity Read ↗

Lack of association of MYO9B genetic variants with coeliac disease in a British cohort.Semantic proximity Read ↗

KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population.Semantic proximity Read ↗

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