Article
Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis.
PloS one - 1 Jan 2013
Nijmeijer Rian M, van Santvoort Hjalmar C, Zhernakova Alexandra, Teller Steffen, Scheiber Jonas A, de Kovel Carolien G, Besselink Marc G H, Visser Jeroen T J, Lutgendorff Femke, Bollen Thomas L, Boermeester Marja A, Rijkers Ger T, Weiss Frank U, Mayerle Julia, Lerch Markus M, Gooszen Hein G, Akkermans Louis M A, Wijmenga Cisca
Abstract excerpt
INTRODUCTION: Impairment of the mucosal barrier plays an important role in the pathophysiology of acute pancreatitis. The myosin IXB (MYO9B) gene and the two tight-junction adaptor genes, PARD3 and MAGI2, have been linked to gastrointestinal permeability. Common variants of these genes are associated with celiac disease and inflammatory bowel disease, two other conditions in which intestinal permeability plays a...
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