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Article

Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans.

Bone - 1 Jan 2008

Cho K, Demissie S, Dupuis J, Cupples L A, Kathiresan S, Beck T J, Karasik D, Kiel D P

Abstract excerpt

Nitric oxide (NO), produced by endothelial cells, is a signaling molecule synthesized from l-arginine by nitric oxide synthases (NOS). NO is known to reduce the ratio of receptor activator of nuclear factor KappaB (RANKL)/osteoprotegerin (OPG), leading to decreased osteoclastogenesis and a reduction in bone resorption. Endothelial nitric oxide synthase (eNOS or NOS3) is the predominant constitutive isoform of...

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Identifiers

PMID: 17980690
DOI: 10.1016/j.bone.2007.09.051
PMCID: PMC2386517

Genes

NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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