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Article

Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1.

Progress in neuro-psychopharmacology & biological psychiatry - 15 Feb 2008

O'Tuathaigh Colm M P, O'Connor Anne-Marie, O'Sullivan Gerard J, Lai Donna, Harvey Richard, Croke David T, Waddington John L

Abstract excerpt

Clinical genetic studies have implicated neuregulin-1 [NRG1] as a leading susceptibility gene for schizophrenia. NRG1 is known to play a significant role in the developing brain, which is consistent with the prevailing neurodevelopmental model of schizophrenia. Thus, the emotional and social phenotype of adult mice with heterozygous 'knockout' of transmembrane [TM]-domain NRG1 was examined further in both sexes....

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Source

Identifiers

PMID: 17980471
DOI: 10.1016/j.pnpbp.2007.09.018

Genes

NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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