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Article

Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice.

The European journal of neuroscience - 1 Jan 2010

O'Tuathaigh C M P, Harte M, O'Leary C, O'Sullivan G J, Blau C, Lai D, Harvey R P, Tighe O, Fagan A J, Kerskens C, Reynolds G P, Waddington J L

Abstract excerpt

Neuregulin-1 (NRG1) has been shown to play a role in glutamatergic neurotransmission and is a risk gene for schizophrenia, in which there is evidence for hypoglutamatergic function. Sensitivity to the behavioural effects of the psychotomimetic N-methyl-D-aspartate receptor antagonists MK-801 and...

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Source

Identifiers

PMID: 20074216
DOI: 10.1111/j.1460-9568.2009.07069.x

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20074216-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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