Article
Parent-of-origin effects on schizophrenia-relevant behaviours of type III neuregulin 1 mutant mice.
Behavioural brain research - 14 Aug 2017
Shang Kani, Talmage David A, Karl Tim
Abstract excerpt
A robust, disease-relevant phenotype is paramount to the validity of genetic mouse models, which are an important tool in understanding complex diseases. Recent evidence from genome-wide association studies suggests the genetic contribution of parents to offspring is not equivalent. Despite this, few studies to date have examined the potential impact of parent genotype (i.e. origin of mutation) on the offspring...
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