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Article

Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

Behavioral neuroscience - 1 Dec 2015

Dachtler James, Ivorra Jose L, Rowland Tessa E, Lever Colin, Rodgers R John, Clapcote Steven J

Abstract excerpt

The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions affecting NRXN1 and NRXN2, encoding α-neurexin I (Nrxn1α) and α-neurexin II (Nrxn2α), in individuals with autism spectrum disorders and schizophrenia. However, the link between α-neurexin deficiency and the manifestation of psychiatric disorders remain unclear. To assess whether the...

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Source

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Identifiers

PMID: 26595880
DOI: 10.1037/bne0000108
PMCID: PMC4655861

Genes

NRXN1
NRXN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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