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Article

Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent.

American journal of physiology. Cell physiology - 1 Jan 2008

Matsuda James J, Filali Mohammed S, Volk Kenneth A, Collins Malia M, Moreland Jessica G, Lamb Fred S

Abstract excerpt

ClC-3 is a member of the ClC family of anion channels/transporters. Recently, the closely related proteins ClC-4 and ClC-5 were shown to be Cl(-)/H(+) antiporters (39, 44). The function of ClC-3 has been controversial. We studied anion currents in HEK293T cells expressing wild-type or mutant ClC-3. The basic biophysical properties of ClC-3 currents were very similar to those of ClC-4 and ClC-5, and distinct from...

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Identifiers

PMID: 17977943
DOI: 10.1152/ajpcell.00338.2007

Genes

CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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