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Article

NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter.

American journal of physiology. Renal physiology - 1 Dec 2005

Mercado Adriana, Vázquez Norma, Song Luyan, Cortés Rosa, Enck Alissa H, Welch Rick, Delpire Eric, Gamba Gerardo, Mount David B

Abstract excerpt

The SLC12A6 gene encoding the K(+)-Cl(-) cotransporter KCC3 is expressed in multiple tissues, including kidney. Here, we report the molecular characterization of several NH(2)-terminal isoforms of human and mouse KCC3, along with intrarenal localization and functional characterization in Xenopus laevis oocytes. Two major isoforms, KCC3a and KCC3b, are generated by transcriptional initiation 5' of two distinct...

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PMID: 16048901
DOI: 10.1152/ajprenal.00464.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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