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Article

The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression.

The Journal of biological chemistry - 9 Jul 2010

Neagoe Ioana, Stauber Tobias, Fidzinski Pawel, Bergsdorf Eun-Yeong, Jentsch Thomas J

Abstract excerpt

Members of the CLC protein family of Cl(-) channels and transporters display the remarkable ability to function as either chloride channels or Cl(-)/H(+) antiporters. Due to the intracellular localization of ClC-6 and ClC-7, it has not yet been possible to study the biophysical properties of these members of the late endosomal/lysosomal CLC branch in heterologous expression. Whereas recent data suggest that ClC-7...

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Identifiers

PMID: 20466723
DOI: 10.1074/jbc.M110.125971
PMCID: PMC2898453

Genes

CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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