Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of ClC-3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter.

The Journal of physiology - 1 Sept 2018

Rohrbough Jeffrey, Nguyen Hong-Ngan, Lamb Fred S

Abstract excerpt

KEY POINTS: The ClC-3 2Cl- /1H+ exchanger modulates endosome pH and Cl- concentration. We investigated the relationships between ClC-3-mediated ion transport (steady-state transport current, ISS ), gating charge (Q) and cytoplasmic alkalization. ClC-3 transport is functionally unidirectional. ClC-5 and ClC-3 display indistinguishable exchange ratios, but ClC-3 cycling is less "efficient", as reflected by a large...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anions
Share to Chloride Channels
Share to Glutamic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Ion Channel Gating

Share to Ion Transport

Share to Protons

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 29917234
DOI: 10.1113/JP276332
PMCID: PMC6117567

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of ClC-3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter.PMID 29917234Read ↗

Separate ion pathways in a Cl-/H+ exchanger.Semantic proximity Read ↗

Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent.Semantic proximity Read ↗

Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P <sub>2</sub>Semantic proximity Read ↗

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease.Semantic proximity Read ↗

A novel CLCN5 pathogenic mutation supports Dent disease with normal endosomal acidification.Semantic proximity Read ↗

ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity.Semantic proximity Read ↗

Intracellular proton regulation of ClC-0.Semantic proximity Read ↗

Molecular Simulations Meet Personalized Medicine. The Mechanism of Action of ClC-5 Antiporter and the Origin of Dent’s DiseaseSemantic proximity Read ↗

Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter.Semantic proximity Read ↗

Divergent Cl <sup>−</sup> and H <sup>+</sup> pathways underlie transport coupling and gating in CLC exchangers and channelsSemantic proximity Read ↗

Proton selective conductance and gating of lysosomal cation channel TMEM175Semantic proximity Read ↗

Direct endosomal acidification by the outwardly rectifying CLC-5 Cl(-)/H(+) exchanger.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.