Article
Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.
Journal of neurochemistry - 1 Feb 2008
Fan Mannie M Y, Zhang Hong, Hayden Michael R, Pelech Steven L, Raymond Lynn A
Abstract excerpt
Huntington's disease is caused by a polyglutamine expansion in the huntingtin (htt) protein, and previous data indicate that over-activation of NMDA receptors (NMDARs) may be involved in the selective degeneration of cells expressing NR1/NR2B NMDARs. We used Kinetworkstrade mark multi-immunoblotting screens to examine expression of 76 protein kinases, 18 protein phosphatases, 25 heat shock/stress proteins, and 27...
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