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Article

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.

Journal of neurochemistry - 1 May 1999

Chen N, Luo T, Wellington C, Metzler M, McCutcheon K, Hayden M R, Raymond L A

Abstract excerpt

Evidence suggests that NMDA receptor-mediated neurotoxicity plays a role in the selective neurodegeneration underlying Huntington's disease (HD). The gene mutation that causes HD encodes an expanded polyglutamine tract of >35 in huntingtin, a protein of unknown function. Both huntingtin and NMDA receptors interact with cytoskeletal proteins, and, for NMDA receptors, such interactions regulate surface expression...

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Source

Identifiers

PMID: 10217265
DOI: 10.1046/j.1471-4159.1999.0721890.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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