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Article

Mutant huntingtin enhances excitotoxic cell death.

Molecular and cellular neurosciences - 1 Jan 2001

Zeron M M, Chen N, Moshaver A, Lee A T, Wellington C L, Hayden M R, Raymond L A

Abstract excerpt

Evidence suggests overactivation of NMDA-type glutamate receptors (NMDARs) contributes to selective degeneration of medium-sized spiny striatal neurons in Huntington's disease (HD). Here we determined whether expression of huntingtin containing the polyglutamine expansion augments NMDAR-mediated excitotoxicity. HEK293 cells coexpressing mutant huntingtin (htt-138Q) and either NR1A/NR2A- or NR1A/NR2B-type NMDARs...

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Identifiers

PMID: 11161468
DOI: 10.1006/mcne.2000.0909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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