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Article

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.

Human molecular genetics - 15 May 2011

Munsie Lise, Caron Nicholas, Atwal Randy Singh, Marsden Ian, Wild Edward J, Bamburg James R, Tabrizi Sarah J, Truant Ray

Abstract excerpt

Huntington's disease (HD) is caused by an expanded CAG tract in the Interesting transcript 15 (IT15) gene encoding the 350 kDa huntingtin protein. Cellular stresses can trigger the release of huntingtin from the endoplasmic reticulum, allowing huntingtin nuclear entry. Here, we show that endogenous, full-length huntingtin localizes to nuclear cofilin-actin rods during stress and is required for the proper stress...

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Identifiers

PMID: 21355047
DOI: 10.1093/hmg/ddr075
PMCID: PMC3080606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.PMID 21355047Read ↗

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