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Article

Kinase inhibitors modulate huntingtin cell localization and toxicity.

Nature chemical biology - 29 May 2011

Atwal Randy Singh, Desmond Carly R, Caron Nicholas, Maiuri Tamara, Xia Jianrun, Sipione Simonetta, Truant Ray

Abstract excerpt

Two serine residues within the first 17 amino acid residues of huntingtin (N17) are crucial for modulation of mutant huntingtin toxicity in cell and mouse genetic models of Huntington's disease. Here we show that the stress-dependent phosphorylation of huntingtin at Ser13 and Ser16 affects N17 conformation and targets full-length huntingtin to chromatin-dependent subregions of the nucleus, the mitotic spindle and...

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Identifiers

PMID: 21623356
DOI: 10.1038/nchembio.582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Kinase inhibitors modulate huntingtin cell localization and toxicity.PMID 21623356Read ↗

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Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region.Semantic proximity Read ↗

Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation.Semantic proximity Read ↗

N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice.Semantic proximity Read ↗

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.Semantic proximity Read ↗

Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila.Semantic proximity Read ↗

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.Semantic proximity Read ↗

Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity.Semantic proximity Read ↗

Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.Semantic proximity Read ↗

An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1.Semantic proximity Read ↗

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