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Article

Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease.

Journal of neurochemistry - 1 Oct 2003

Zemskov Evgeny A, Jana Nihar R, Kurosawa Masaru, Miyazaki Haruko, Sakamoto Naoaki, Nekooki Munenori, Nukina Nobuyuki

Abstract excerpt

In order to investigate any effect of truncated mutant huntingtin (tNhtt) aggregation on protein kinase C (PKC) signaling in Huntington's disease (HD), we studied a possible association of PKC isoforms with the aggregates using cellular and transgenic models of HD. In this report we describe an association of mutant tNhtt with at least three PKC isoforms (alpha, delta, zeta), as revealed by co-immunoprecipitation...

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PMID: 14511117
DOI: 10.1046/j.1471-4159.2003.02002.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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