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Altered NMDA Receptor Trafficking in a Yeast Artificial Chromosome Transgenic Mouse Model of Huntington's Disease

4 Apr 2007

Abstract excerpt

Overactivation of NMDA receptors (NMDARs) is believed to play a role in degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD). This hereditary disorder is caused by an expansion >35 in the polyglutamine (polyQ) region of the protein huntingtin (htt). Previous work has shown that NMDAR current, calcium signaling, and/or toxicity are enhanced in striatal MSNs in a variety of...

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PMID: 17409241
DOI: 10.1523/jneurosci.4356-06.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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