Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of polyglutamine-expanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors.

The Journal of biological chemistry - 29 Aug 2003

Song Cheng, Zhang Yuntian, Parsons Chris G, Liu Ya Fang

Abstract excerpt

In our previous studies, we found that expression of polyglutamine-expanded huntingtin in HN33 cells induced sensitization of N-methyl-D-aspartate (NMDA) receptors (Sun, Y., Savinainen, A., and Liu, Y. F. (2001) J. Biol. Chem. 276, 24713-24718). Following this study, we investigated whether tyrosine phosphorylation of NMDA receptors might contribute to the altered property of the receptors. Expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Enzyme Inhibitors
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to N-Methylaspartate

Share to Precipitin Tests

Share to Receptors, N-Methyl-D-Aspartate

Share to Tyrosine

Source

Identifiers

PMID: 12810713
DOI: 10.1074/jbc.M304240200

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of polyglutamine-expanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors.PMID 12810713Read ↗

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.Semantic proximity Read ↗

Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.Semantic proximity Read ↗

Altered NMDA Receptor Trafficking in a Yeast Artificial Chromosome Transgenic Mouse Model of Huntington's DiseaseSemantic proximity Read ↗

Mutant huntingtin enhances excitotoxic cell death.Semantic proximity Read ↗

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.Semantic proximity Read ↗

Neuroprotective strategies for NMDAR-mediated excitotoxicity in Huntington’s DiseaseSemantic proximity Read ↗

Role of phosphorylated Y1252, Y1336 and Y1472 on NR2B subunits in hypoxia tolerance of neuronal cell in vitro.Semantic proximity Read ↗

Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.Semantic proximity Read ↗

Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophreniaSemantic proximity Read ↗

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.Semantic proximity Read ↗

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.Semantic proximity Read ↗

NMDA receptor/amyloid precursor protein interactions: a comparison between wild-type and amyloid precursor protein mutations associated with familial Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.