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Article

Testing and estimating gene-environment interactions in family-based association studies.

Biometrics - 1 Jun 2008

Vansteelandt Stijn, Demeo Dawn L, Lasky-Su Jessica, Smoller Jordan W, Murphy Amy J, McQueen Matt, Schneiter Kady, Celedon Juan C, Weiss Scott T, Silverman Edwin K, Lange Christoph

Abstract excerpt

We propose robust and efficient tests and estimators for gene-environment/gene-drug interactions in family-based association studies in which haplotypes, dichotomous/quantitative phenotypes, and complex exposure/treatment variables are analyzed. Using causal inference methodology, we show that the tests and estimators are robust against unmeasured confounding due to population admixture and stratification,...

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Identifiers

PMID: 17970814
DOI: 10.1111/j.1541-0420.2007.00925.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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