Article
Gene-environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach.
Biostatistics (Oxford, England) - 1 Jul 2012
Fardo David W, Liu Jinze, Demeo Dawn L, Silverman Edwin K, Vansteelandt Stijn
Abstract excerpt
We propose a method for testing gene-environment (G × E) interactions on a complex trait in family-based studies in which a phenotypic ascertainment criterion has been imposed. This novel approach employs G-estimation, a semiparametric estimation technique from the causal inference literature, to avoid modeling of the association between the environmental exposure and the phenotype, to gain robustness against...
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