Article
A general semi-parametric approach to the analysis of genetic association studies in population-based designs.
BMC genetics - 28 Feb 2013
Lutz Sharon, Yip Wai-Ki, Hokanson John, Laird Nan, Lange Christoph
Abstract excerpt
BACKGROUND: For genetic association studies in designs of unrelated individuals, current statistical methodology typically models the phenotype of interest as a function of the genotype and assumes a known statistical model for the phenotype. In the analysis of complex phenotypes, especially in the presence of ascertainment conditions, the specification of such model assumptions is not straight-forward and is...
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