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Article

Family-based gene-by-environment interaction studies: revelations and remedies.

Epidemiology (Cambridge, Mass.) - 1 May 2011

Shi Min, Umbach David M, Weinberg Clarice R

Abstract excerpt

Bias can arise in case-control studies of genotype effects if the underlying population is structured (genetically stratified or admixed). Nuclear-family-based studies enjoy robustness against such bias, provided that inference conditions properly on the parents. Investigators have extended family-based methods to study gene-by-environment interactions, regarding such extensions as retaining robustness. We...

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Identifiers

PMID: 21490534
DOI: 10.1097/EDE.0b013e318212fec6
PMCID: PMC3132804

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