Article
Confidence intervals for candidate gene effects and environmental factors in population-based association studies of families.
Annals of human genetics - 1 Jul 2007
Shin Janey, Darlington Gerarda A, Cotton Cecilia, Corey Mary, Bull Shelley B
Abstract excerpt
Complex diseases are influenced by both genetic and environmental factors. Studies of individuals or of families can be used to examine the association of genetic factors, such as candidate genes, and other risk factors with the presence or absence of complex disorders. If families are investigated, whether or not they are randomly ascertained, possible familial correlation among observations must be considered....
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