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Article

X chromosome inactivation in females with multiple sclerosis.

European journal of neurology - 1 Dec 2007

Knudsen G P S, Harbo H F, Smestad C, Celius E G, Akesson E, Oturai A, Ryder L P, Spurkland A, Ørstavik K H

Abstract excerpt

The aetiology of multiple sclerosis (MS) is unknown. Autoimmune mechanisms are most probably involved. Loss of immunological tolerance to self-antigens is a common feature of autoimmune disorders. Response to X-linked self-antigens could be influenced by X-chromosome inactivation, and contribute to the gender bias observed in autoimmune disorders. Previous studies have indicated an association between skewed X...

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Identifiers

PMID: 17970735
DOI: 10.1111/j.1468-1331.2007.01987.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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