Article
The X chromosome in female-predominant autoimmune diseases.
Annals of the New York Academy of Sciences - 1 Sept 2007
Invernizzi Pietro
Abstract excerpt
Autoimmune diseases affect approximately 5% of the population in Western countries, with high female predominance. Family and twins studies have demonstrated that genetic factors are crucial determinants of susceptibility to autoimmune disease, but no specific genes have yet been identified. Recent studies indicate that X chromosome abnormalities, such as monosomy rates and inactivation patterns, occur in a...
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