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Sex Bias in Systemic Sclerosis: from Clinical to Immunological Differences

27 May 2025

Abstract excerpt

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microvasculopathy, extensive fibrosis, and autoantibodies. The disease affects mostly the female sex. In this review, we highlight sex bias in clinical manifestations in SSc, and the pathophysiological changes underlying this bias. Male sex is associated with the diffuse cutaneous form of the disease, digital ulcers, interstitial lung...

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Eosinophilic Disorders and Syndromes
Mast cells and histamine
Systemic Sclerosis and Related Diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40423726
DOI: 10.1007/s12016-025-09062-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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