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Article

Reduced receptor editing in lupus-prone MRL/lpr mice.

The Journal of experimental medicine - 26 Nov 2007

Lamoureux Jennifer L, Watson Lisa C, Cherrier Marie, Skog Patrick, Nemazee David, Feeney Ann J

Abstract excerpt

The initial B cell repertoire contains a considerable proportion of autoreactive specificities. The first major B cell tolerance checkpoint is at the stage of the immature B cell, where receptor editing is the primary mode of eliminating self-reactivity. The cells that emigrate from the bone marrow have a second tolerance checkpoint in the transitional compartment in the spleen. Although it is known that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lupus Erythematosus, Systemic

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Source

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Identifiers

PMID: 17967905
DOI: 10.1084/jem.20071268
PMCID: PMC2118512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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