Receptor editing: an approach by autoreactive B cells to escape tolerance.

doi:10.1084/jem.177.4.999

Article

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1 Apr 1993

Abstract excerpt

To determine the fate of anti-DNA antibody-bearing B cells in normal mice, we generated transgenic mice bearing the heavy (H) and light (L) chain genes of a well-characterized anti-double-stranded DNA antibody. This antibody was originally isolated from a diseased MRL/lpr mouse and has characteristics common to spontaneously arising anti-DNA antibodies. Results show that the H/L transgene (tg) immunoglobulin...

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