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Article

Receptor editing and genetic variability in human autoreactive B cells.

The Journal of experimental medicine - 11 Jan 2016

Lang Julie, Ota Takayuki, Kelly Margot, Strauch Pamela, Freed Brian M, Torres Raul M, Nemazee David, Pelanda Roberta

Abstract excerpt

The mechanisms by which B cells undergo tolerance, such as receptor editing, clonal deletion, and anergy, have been established in mice. However, corroborating these mechanisms in humans remains challenging. To study how autoreactive human B cells undergo tolerance, we developed a novel humanized mouse model. Mice expressing an anti-human Igκ membrane protein to serve as a ubiquitous neo self-antigen (Ag) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26694971
DOI: 10.1084/jem.20151039
PMCID: PMC4710202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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