Article
Positive selection of natural poly-reactive B cells in the periphery occurs independent of heavy chain allelic inclusion.
PloS one - 1 Jan 2015
Xing Ying, Ji Qiuhe, Lin Ying, Fu Meng, Gao Jixin, Zhang Ping, Hu Xingbin, Feng Lei, Liu Yufeng, Han Hua, Li Wei
Abstract excerpt
Natural autoreactive B cells are important mediators of autoimmune diseases. Receptor editing is known to play an important role in both central and peripheral B cell tolerance. However, the role of allelic inclusion in the development of natural autoreactive B cells is not clear. Previously, we generated μ chain (TgV(H)3B4I) and μ/κ chains (TgV(H/L)3B4) transgenic mice using transgene derived from the 3B4...
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