Article
Receptor editing: genetic reprogramming of autoreactive lymphocytes.
Cell biochemistry and biophysics - 1 Jan 1999
Retter M W, Nemazee D
Abstract excerpt
The clonal selection theory postulates that immune tolerance mediated selection occurs at the level of the cell. The receptor editing model, instead, suggests that selection occurs at the level of the B-cell receptor, so that self-reactive receptors that encounter autoantigen in the bone marrow are altered through secondary rearrangement. Recent studies in transgenic model systems and normal B cells, both in vivo...
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