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Article

Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements.

Clinical pharmacology and therapeutics - 1 Apr 2006

Aquilante Christina L, Langaee Taimour Y, Lopez Larry M, Yarandi Hossein N, Tromberg Jennifer S, Mohuczy Dagmara, Gaston Katherine L, Waddell Cassandra D, Chirico Mark J, Johnson Julie A

Abstract excerpt

INTRODUCTION: The primary objective of this study was to determine whether variability in warfarin dose requirements is determined by common polymorphisms in genes whose products are involved in the pharmacodynamics and pharmacokinetics of warfarin, namely, the coagulation factors, vitamin K epoxide reductase complex subunit 1 (VKORC1), and cytochrome P450 (CYP) 2C9. METHODS: Patients (N = 350) receiving stable...

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Source

Identifiers

PMID: 16580898
DOI: 10.1016/j.clpt.2005.11.011

Genes

VKORC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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