Article
A human postnatal lymphoid progenitor capable of circulating and seeding the thymus.
The Journal of experimental medicine - 24 Dec 2007
Six Emmanuelle M, Bonhomme Delphine, Monteiro Marta, Beldjord Kheira, Jurkowska Monika, Cordier-Garcia Corinne, Garrigue Alexandrine, Dal Cortivo Liliane, Rocha Benedita, Fischer Alain, Cavazzana-Calvo Marina, André-Schmutz Isabelle
Abstract excerpt
Identification of a thymus-seeding progenitor originating from human bone marrow (BM) constitutes a key milestone in understanding the mechanisms of T cell development and provides new potential for correcting T cell deficiencies. We report the characterization of a novel lymphoid-restricted subset, which is part of the lineage-negative CD34(+)CD10(+) progenitor population and which is distinct from B...
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