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Article

Dynamics of thymus-colonizing cells during human development.

Immunity - 1 Feb 2006

Haddad Rima, Guimiot Fabien, Six Emmanuelle, Jourquin Frederic, Setterblad Niclas, Kahn Edmond, Yagello Micael, Schiffer Cecile, Andre-Schmutz Isabelle, Cavazzana-Calvo Marina, Gluckman Jean Claude, Delezoide Anne-Lise, Pflumio Françoise, Canque Bruno

Abstract excerpt

Here, we identify fetal bone marrow (BM)-derived CD34hiCD45RAhiCD7+ hematopoietic progenitors as thymus-colonizing cells. This population, virtually absent from the fetal liver (FL), emerges in the BM by development weeks 8-9, where it accumulates throughout the second trimester, to finally decline around birth. Based on phenotypic, molecular, and functional criteria, we demonstrate that CD34hiCD45RAhiCD7+ cells...

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Identifiers

PMID: 16473833
DOI: 10.1016/j.immuni.2006.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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