Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential

30 Dec 2005

Abstract excerpt

It is a longstanding question which bone marrow-derived cell seeds the thymus and to what level this cell is committed to the T-cell lineage. We sought to elucidate this issue by examining gene expression, lineage potential, and self-renewal capacity of the 2 most immature subsets in the human thymus, namely CD34+ CD1a- and CD34+ CD1a+ thymocytes. DNA microarrays revealed the presence of several myeloid and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to Single-cell and spatial transcriptomics
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16384926
DOI: 10.1182/blood-2005-08-3412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potentialPMID 16384926Read ↗

Identification of human T-lymphoid progenitor cells in CD34+ CD38low and CD34+ CD38+ subsets of human cord blood and bone marrow cells using NOD-SCID fetal thymus organ cultures.Semantic proximity Read ↗

A human postnatal lymphoid progenitor capable of circulating and seeding the thymus.Semantic proximity Read ↗

Circulating hematopoietic progenitors with T lineage potential.Semantic proximity Read ↗

Notch1 and IL-7 Receptor Interplay Maintains Proliferation of Human Thymic Progenitors while Suppressing Non-T Cell FatesSemantic proximity Read ↗

A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesisSemantic proximity Read ↗

Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymusSemantic proximity Read ↗

Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors.Semantic proximity Read ↗

The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus OrganogenesisSemantic proximity Read ↗

The Development of T Cells From Stem Cells in Mice and HumansSemantic proximity Read ↗

The development of T and non-T cell lineages from CD34+ human thymic precursors can be traced by the differential expression of CD44.Semantic proximity Read ↗

Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult ThymusSemantic proximity Read ↗

Integration of Hematopoietic and Thymus-like Niches in a Human iPSC-derived Bone Marrow OrganoidSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.