Article
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
Atherosclerosis - 1 May 2008
Assimes Themistocles L, Knowles Joshua W, Priest James R, Basu Analabha, Borchert Astrid, Volcik Kelly A, Grove Megan L, Tabor Holly K, Southwick Audrey, Tabibiazar Raymond, Sidney Steve, Boerwinkle Eric, Go Alan S, Iribarren Carlos, Hlatky Mark A, Fortmann Stephen P, Myers Richard M, Kuhn Hartmut, Risch Neil, Quertermous Thomas
Abstract excerpt
OBJECTIVE: Murine genetic models suggest that function of the 12/15-LOX enzyme promotes atherosclerosis. We tested the hypothesis that exonic and/or promoter single nucleotide polymorphisms (SNPs) in the human 12/15-LOX gene (ALOX15) alter the risk of symptomatic coronary artery disease (CAD). METHODS AND RESULTS: We resequenced ALOX15 and then genotyped a common promoter and a less common novel coding SNP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.