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Article

cis-Acting elements within the Candida albicans ERG11 promoter mediate the azole response through transcription factor Upc2p.

Eukaryotic cell - 1 Dec 2007

Oliver Brian G, Song Jia L, Choiniere Jake H, White Theodore C

Abstract excerpt

The azole antifungal drugs are used to treat infections caused by Candida albicans and other fungi. These drugs interfere with the biosynthesis of ergosterol, the major sterol in fungal cells, by inhibiting an ergosterol biosynthetic enzyme, lanosterol 14 alpha-demethylase, encoded by the ERG11 gene. In vitro, these drugs as well as other ergosterol biosynthesis inhibitors increase ERG11 mRNA expression by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17951521
DOI: 10.1128/EC.00331-06
PMCID: PMC2168239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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cis-Acting elements within the Candida albicans ERG11 promoter mediate the azole response through transcription factor Upc2p.PMID 17951521Read ↗

The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.Semantic proximity Read ↗

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