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Article

The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.

Antimicrobial agents and chemotherapy - 1 Apr 2004

Song Jia L, Harry Jo Beth, Eastman Richard T, Oliver Brian G, White Theodore C

Abstract excerpt

The azole antifungal drugs that target lanosterol 14-alpha-demethylase, encoded by the ERG11 gene, are used to treat a variety of infections caused by Candida albicans. Azoles are known to induce expression of ERG11 mRNA. The ERG11 promoter was cloned 5' of the luciferase-coding region, and the i...

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Identifiers

PMID: 15047513
DOI: 10.1128/AAC.48.4.1136-1144.2004
PMCID: PMC375326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15047513-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.PMID 15047513Read ↗

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