Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.

Antimicrobial agents and chemotherapy - 1 Apr 2004

Song Jia L, Harry Jo Beth, Eastman Richard T, Oliver Brian G, White Theodore C

Abstract excerpt

The azole antifungal drugs that target lanosterol 14-alpha-demethylase, encoded by the ERG11 gene, are used to treat a variety of infections caused by Candida albicans. Azoles are known to induce expression of ERG11 mRNA. The ERG11 promoter was cloned 5' of the luciferase-coding region, and the induction of ERG11 expression by azoles was monitored by luciferase assays. Maximal induction of the ERG11 promoter by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Azoles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Candida albicans

Share to Electroporation

Share to Enzyme Induction

Share to Ergosterol

Share to Sterol 14-Demethylase

Share to Sterols

Source

Open in PubMed Open full text

Identifiers

PMID: 15047513
DOI: 10.1128/AAC.48.4.1136-1144.2004
PMCID: PMC375326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Candida albicans lanosterol 14-alpha-demethylase (ERG11) gene promoter is maximally induced after prolonged growth with antifungal drugs.PMID 15047513Read ↗

cis-Acting elements within the Candida albicans ERG11 promoter mediate the azole response through transcription factor Upc2p.Semantic proximity Read ↗

Ergosterol gene expression in wild-type and ergosterol-deficient mutants of Candida albicans.Semantic proximity Read ↗

Azole-Resistant Alleles of ERG11 in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors.Semantic proximity Read ↗

Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrataSemantic proximity Read ↗

The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus speciesSemantic proximity Read ↗

Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans.Semantic proximity Read ↗

Genomic Profiling of the Response of Candida albicans to Itraconazole Treatment Using a DNA MicroarraySemantic proximity Read ↗

<i>C. albicans</i> ergosterol modulates the antifungal response of human neutrophils by masking β-glucanSemantic proximity Read ↗

Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site.Semantic proximity Read ↗

Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents.Semantic proximity Read ↗

Reduced susceptibility of Candida albicans clinical isolates to azoles and detection of mutations in the ERG11 gene.Semantic proximity Read ↗

Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.