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Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening

19 Oct 2007

Abstract excerpt

The propagation of the hepatitis C virus (HCV) is a complex process that requires both host and viral proteins. To facilitate identification of host cell factors that are required for HCV replication, we screened a panel of small interference RNAs that preferentially target human protein kinases using an HCV replicon expressing the firefly luciferase gene as a genetic reporter. Small interference RNAs specific...

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PMID: 17951261
DOI: 10.1074/jbc.m703988200

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