Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.

doi:10.1128/JVI.02418-08

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Article

Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.

Journal of virology - 1 Oct 2009

Borawski Jason, Troke Philip, Puyang Xiaoling, Gibaja Veronica, Zhao Shanchaun, Mickanin Craig, Leighton-Davies Juliet, Wilson Christopher J, Myer Vic, Cornellataracido Ivan, Baryza Jeremy, Tallarico John, Joberty Gerard, Bantscheff Marcus, Schirle Markus, Bouwmeester Tewis, Mathy Joanna E, Lin Kai, Compton Teresa, Labow Mark, Wiedmann Brigitte, Gaither L Alex

Abstract excerpt

Host factor pathways are known to be essential for hepatitis C virus (HCV) infection and replication in human liver cells. To search for novel host factor proteins required for HCV replication, we screened a subgenomic genotype 1b replicon cell line (Luc-1b) with a kinome and druggable collection of 20,779 siRNAs. We identified and validated several enzymes required for HCV replication, including class III...

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PMID: 19605471
DOI: 10.1128/JVI.02418-08
PMCID: PMC2748049

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