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Article

Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening

16 Jul 2009

Abstract excerpt

ABSTRACT The entry pathway of the hepatitis C virus (HCV), a major human pathogen, into the cell is incompletely defined. To better characterize this viral life cycle stage, we screened a small interfering RNA library dedicated to the membrane trafficking and remodeling with the infection model of Huh‐7.5.1 cells by HCV pseudoparticles (HCVpp). Results showed that the down‐regulation of different factors implied...

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PMID: 19608626
DOI: 10.1096/fj.09-131920

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