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STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α

8 Dec 2016

Abstract excerpt

Interferon-α (IFN-α) and IFN-λ are structurally distinct cytokines that bind to different receptors, but induce expression of similar sets of genes through Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathways. The difference between IFN-α and IFN-λ signaling remains poorly understood. Here, using the CRISPR/Cas9 system, we examine the role of STAT1 and STAT2 in the inhibition of...

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PMID: 27929099
DOI: 10.1038/srep38336

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