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Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza

25 Jan 2014

Abstract excerpt

During viral infection of human cells, host kinases mediate signaling activities that are used by all viruses for replication; therefore, targeting of host kinases is of broad therapeutic interest. Here, host kinases were globally screened during human influenza virus (H1N1) infection to determine the time-dependent effects of virus infection and replication on kinase function. Desthiobiotin-labeled analogs of...

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PMID: 24464431
DOI: 10.1177/1087057113518068

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