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Article

NS5A--from obscurity to new target for HCV therapy.

Recent patents on anti-infective drug discovery - 1 Jun 2008

Schmitz Uli, Tan Seng-Lai

Abstract excerpt

The hepatitis C virus (HCV) non-structural 5A (NS5A) protein is essential for viral RNA replication and may play a role in subverting host intracellular signaling pathways. Although no intrinsic enzymatic activity has been ascribed to NS5A, this proline-rich hydrophilic phosphoprotein is likely to exert its functions by interacting with viral and cellular factors. Recent studies using the HCV replicon cell...

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Identifiers

PMID: 18673121
DOI: 10.2174/157489108784746597

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