Article
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.
Diabetes - 1 Oct 2000
Kossila M, Sinkovic M, Kärkkäinen P, Laukkanen M O, Miettinen R, Rissanen J, Kekäläinen P, Kuusisto J, Ylä-Herttuala S, Laakso M
Abstract excerpt
Phosphatidylinositol (PI) 3-kinase is a key signaling molecule in insulin-stimulated glucose transport. Therefore, we investigated the catalytic subunit p110beta, of human PI 3-kinase as a candidate gene for type 2 diabetes. Human p110beta gene was cloned from the placental genomic library. All 22 exons, intronic regions flanking the exons and 1.5 kb of the proximal/5' region of the p110beta gene, were screened...
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